Mechanisms of neutrophil-mediated disease: innovative therapeutic interventions.

  title={Mechanisms of neutrophil-mediated disease: innovative therapeutic interventions.},
  author={Thea Magrone and Emilio Jirillo},
  journal={Current pharmaceutical design},
  volume={18 12},
Over recent years, neutrophil functions have extensively been reevaluted. For instance, it has been found that extracellular traps generated by activated neutrophils are able to perform a very effective antimicrobial activity against a plethora of microorganisms. In addition, neutrophils possess the ability to interact with monocytes/macrophages either via release of their granule content or via efferocytosis. Efferocytosis is based on neutrophil clearance by macrophages, which, in turn, exert… CONTINUE READING
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