Mechanisms of neurotoxicity: applications to human biomonitoring.

  title={Mechanisms of neurotoxicity: applications to human biomonitoring.},
  author={Luigi Manzo and Anna F. Castoldi and Teresa Coccini and Anna D. Rossi and Pierluigi Nicotera and Lucio Guido Costa},
  journal={Toxicology letters},
  volume={77 1-3},
Interactions of chemicals with cerebral neurotransmitters, receptors, and second messenger systems are often accompanied by similar changes involving components in non-neural tissues. On this basis, indirect strategies have been developed to investigate neural cell function parameters by methods using accessible cells such as platelets or peripheral blood lymphocytes. The validity of certain surrogate markers of biochemical events occurring in the nervous system has been documented by recent… CONTINUE READING


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