Mechanisms of neurodegeneration in amyotrophic lateral sclerosis.

@article{Cluskey2001MechanismsON,
  title={Mechanisms of neurodegeneration in amyotrophic lateral sclerosis.},
  author={S Cluskey and David Boyer Ramsden},
  journal={Molecular pathology : MP},
  year={2001},
  volume={54 6},
  pages={386-92}
}
Amyotrophic lateral sclerosis (ALS) is the most common variant of motor neurone disease affecting adults that usually strikes during mid to late life. Its aetiology is still poorly understood, although a major breakthrough came with the discovery that mutations in the Cu/Zn superoxide dismutase (SOD1) gene affect approximately 20% of patients with familial ALS. Experiments using both transgenic mice and ALS tissues have been useful in delineating other genetic defects in ALS. However, because… CONTINUE READING

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