Mechanisms of neurodegeneration in amyotrophic lateral sclerosis.

  title={Mechanisms of neurodegeneration in amyotrophic lateral sclerosis.},
  author={S Cluskey and David Boyer Ramsden},
  journal={Molecular pathology : MP},
  volume={54 6},
Amyotrophic lateral sclerosis (ALS) is the most common variant of motor neurone disease affecting adults that usually strikes during mid to late life. Its aetiology is still poorly understood, although a major breakthrough came with the discovery that mutations in the Cu/Zn superoxide dismutase (SOD1) gene affect approximately 20% of patients with familial ALS. Experiments using both transgenic mice and ALS tissues have been useful in delineating other genetic defects in ALS. However, because… CONTINUE READING


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Amyotrophic lateral sclerosislinked glutamate transporter mutant has impaired glutamate clearance capacity

  • M Aoki, CL Lin, JD Rothstein
  • J Biol Chem
  • 2001

Glutamate transporters in neurologic disease

  • M Jackson, G Steers, PN Leigh
  • Arch Neurol
  • 2001

Increased expression of neuronal nitric oxide synthase spliced variants in reactive astrocytes of amyotrophic lateral sclerosis human spinal cord

  • F Facchinetti, M Sasaki, FB Cutting
  • J Neurosci
  • 2001

Current status of SOD 1 mutations in amyotrophic lateral sclerosis

  • PJ Shaw, CJ Eggett
  • Amyo - trophic Lateral Sclerosis and Other Motor…
  • 2000

Glutathione , oxidative stress and neurodegeneration

  • M FlintBeal
  • Eur J Biochem
  • 2000

Immunocytochemical study on the distribution of nitrotyrosine in the brain of the transgenic mice expressing a human Cu / Zn SOD mutation

  • MV Catania, E Aronica, B Yankaya
  • Brain Res
  • 2000

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