Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis

@article{Friese2014MechanismsON,
  title={Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis},
  author={Manuel A Friese and Benjamin Schattling and Lars Fugger},
  journal={Nature Reviews Neurology},
  year={2014},
  volume={10},
  pages={225-238}
}
Multiple sclerosis (MS) is the most frequent chronic inflammatory disease of the CNS, and imposes major burdens on young lives. Great progress has been made in understanding and moderating the acute inflammatory components of MS, but the pathophysiological mechanisms of the concomitant neurodegeneration—which causes irreversible disability—are still not understood. Chronic inflammatory processes that continuously disturb neuroaxonal homeostasis drive neurodegeneration, so the clinical outcome… CONTINUE READING
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Effect of dronabinol on progression in progressive multiple sclerosis (CUPID): a randomised, placebo-controlled trial

  • J Zajicek
  • Lancet Neurol
  • 2013

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