Mechanisms of neuregulin action.

Abstract

Neuregulin 1 (Nrg1) and ErbB receptor tyrosine kinase signalling is essential for the formation and proper functioning of multiple organ systems and inappropriate Nrgl/ErbB signalling severely compromises health, contributing to such diverse pathologies as cancer and neuropsychiatric disorders. Numerous genetic modelling studies in mice demonstrate that Nrg1 signalling is important in the development of normal neuronal connectivity. Recent studies have identified novel signalling mechanisms and revealed unexpected roles of Nrg1 isoforms in both the developing and adult nervous system. Of particular interest to this discussion are findings linking deficits in Nrg1-ErbB4 signalling to perturbations of synaptic transmission, myelination, and the survival of particular sets of neurons and glia.

Statistics

0501001502008200920102011201220132014201520162017
Citations per Year

289 Citations

Semantic Scholar estimates that this publication has 289 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Talmage2008MechanismsON, title={Mechanisms of neuregulin action.}, author={David A Talmage}, journal={Novartis Foundation symposium}, year={2008}, volume={289}, pages={74-84; discussion 84-93} }