Mechanisms of neural specification from embryonic stem cells

  title={Mechanisms of neural specification from embryonic stem cells},
  author={Nicolas Gaspard and Pierre Vanderhaeghen},
  journal={Current Opinion in Neurobiology},
While embryonic stem (ES) cells have been used for several years to generate specific populations of neural cells in a translational perspective, they have also emerged as a promising approach in developmental neurobiology, by providing reductionist models of neural development. Here we review recent work that indicates that ES-based models are not only able to mimic normal brain development, but also provide novel tools to dissect the relative contribution of intrinsic and extrinsic mechanisms… CONTINUE READING


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