2 Signalling mechanisms Glossary Brain ischemia : Decrease in blood flow to the brain that leads to brain dysfunction or cell death
Comprehensive gene expression profiling and proteomic analyses have enabled a deeper molecular and cellular mechanistic understanding of post-injury brain regeneration, aiding the design of novel therapeutic modalities that enhance regeneration.
Injury induced plasticity in primary neuronal culture and the mature brain
Investigation of the reactive and regenerative alterations associated with the neuronal response to structural injury and the effect of the brain penetrant microtubule-stabilizing agent Epothilone D on post-injury axonal sprouting in an in vitro model of CNS trauma demonstrated intrinsic differences in how excitatory neurons and inhibitory interneurons respond to injury.
Astrocyte activation and reactive gliosis—A new target in stroke?
- BiologyNeuroscience Letters
Neuroimmune System as a Driving Force for Plasticity Following CNS Injury
- BiologyFrontiers in Cellular Neuroscience
The mechanisms through which the neuroimmune system mediates plasticity after CNS injury are reviewed to offer valuable therapeutic insight into how to promote adaptive plasticity and/or diminish maladaptive plasticity, respectively.
Neural Plasticity Following Ischemia
The various ways that the existing network can be restructured and neuronal connections can be remodeled after the injury to enable partial or complete recovery of motor function are discussed.
Experience-dependent neural plasticity in the adult damaged brain.
- Psychology, BiologyJournal of communication disorders
Neural plasticity after peripheral nerve injury and regeneration
- BiologyProgress in Neurobiology
Influence of Inflammation on Poststroke Plasticity
- Biology, PsychologyNeural plasticity
This paper attempts to discuss the influence of poststroke inflammatory response on brain plasticity and stroke outcome, and describes the recent anti-inflammatory strategies that have been effective for recovery in experimental stroke.
Neuron-Astrocyte Signaling in the Development and Plasticity of Neural Circuits
Insight into the molecular mechanisms by which astrocytes regulate the wiring of the brain during development could lead to new therapeutic strategies to promote repair and rewiring of neural circuits in the mature brain following CNS injury and neurodegenerative disease.
Adult cortical plasticity following injury: Recapitulation of critical period mechanisms?
- Biology, PsychologyNeuroscience
SHOWING 1-10 OF 61 REFERENCES
Persistent Production of Neurons from Adult Brain Stem Cells During Recovery after Stroke
- BiologyStem cells
It is shown that endogenous neural stem cells continuously supply the injured adult brain with new neurons, which suggests novel self‐repair strategies to improve recovery after stroke.
Inhibition of Nogo: A key strategy to increase regeneration, plasticity and functional recovery of the lesioned central nervous system
- BiologyAnnals of medicine
These studies show that intracerebral application of Nogo‐A‐inactivating reagents leads to enhanced regeneration and compensatory sprouting, structural reorganization or plasticity, and functional recovery as seen in different behavioural analyses.
Neuronal replacement from endogenous precursors in the adult brain after stroke
- BiologyNature Medicine
It is shown that stroke, caused by transient middle cerebral artery occlusion in adult rats, leads to a marked increase of cell proliferation in the subventricular zone, and stroke induces differentiation of new neurons into the phenotype of most of the neurons destroyed by the ischemic lesion.
Experience-Associated Structural Events, Subependymal Cellular Proliferative Activity, and Functional Recovery After Injury to the Central Nervous System
- PsychologyJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
In this article, the authors review the literature on use-dependent morphologic events, focusing on the direct interaction of behavioral experience and structural changes associated with plasticity and degeneration.
Neurogenesis in the Adult Ischemic Brain: Generation, Migration, Survival, and Restorative Therapy
- BiologyThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
Current data on the induction of neurogenesis after stroke in the adult brain is reviewed and insight into the potential for restorative treatments of stroke is provided.
Plasticity of Cortical Projections after Stroke
- Biology, PsychologyThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
Stroke induces a process of remapping and reconnection within the adult brain through changes in neuronal activity that may involve a reactivation of developmental programs in areas connected to the infarct.
Accelerated Glial Reactivity to Stroke in Aged Rats Correlates with Reduced Functional Recovery
- Biology, PsychologyJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
The results suggest that a temporally anomalous gliotic reaction to cerebral ischemia in aged rats leads to the premature formation of scar tissue that impedes functional recovery after stroke.
Inosine induces axonal rewiring and improves behavioral outcome after stroke
- BiologyProceedings of the National Academy of Sciences of the United States of America
It is shown that in adult rats with unilateral cortical infarcts, inosine stimulated neurons on the undamaged side of the brain to extend new projections to denervated areas of the midbrain and spinal cord.
Functional and cellular effects of environmental enrichment after experimental brain infarcts.
- Biology, PsychologyRestorative neurology and neuroscience
Our genes interact with environmental stimuli throughout our lives. The attitude and reaction to an acute cerebral trauma or stroke, as well as the pre-lesion life event and activities, can influence…
Gliosis and brain remodeling after treatment of stroke in rats with marrow stromal cells
This is the first report to show that MSCs injected at 7 days after stroke improve long-term neurological outcome in older animals, and reactive astrocytes responding to MSC treatment of ischemia may also promote axonal regeneration during long‐term recovery.