Mechanisms of nanoparticle-mediated siRNA transfection by melittin-derived peptides.

@article{Hou2013MechanismsON,
  title={Mechanisms of nanoparticle-mediated siRNA transfection by melittin-derived peptides.},
  author={Kirk Kohwa Hou and Hua Pan and Lloyd E. Ratner and Paul H Schlesinger and Samuel A. Wickline},
  journal={ACS nano},
  year={2013},
  volume={7 10},
  pages={
          8605-15
        }
}
Traditional peptide-mediated siRNA transfection via peptide transduction domains exhibits limited cytoplasmic delivery of siRNA due to endosomal entrapment. This work overcomes these limitations with the use of membrane-destabilizing peptides derived from melittin for the knockdown of NFkB signaling in a model of adult T-cell leukemia/lymphoma. While the mechanism of siRNA delivery into the cytoplasmic compartment by peptide transduction domains has not been well studied, our analysis of… CONTINUE READING

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