Mechanisms of myeloma cell growth control.

  title={Mechanisms of myeloma cell growth control.},
  author={Diane F. Jelinek},
  journal={Hematology/oncology clinics of North America},
  volume={13 6},
By necessity, this article focuses on only a handful of molecules with demonstrated ability to affect growth of myeloma cells. The heterogeneity in growth-factor responsiveness has made formulation of a uniform hypothesis a daunting challenge. One trait that appears to be consistent among all myeloma patients is the uncoupling of the normally highly integrated relationship between terminal differentiation and loss of growth potential. Thus, the common feature in myeloma may not be the precise… CONTINUE READING

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