Mechanisms of mutation formation with long-wave ultraviolet light (UVA).

@article{Rnger2008MechanismsOM,
  title={Mechanisms of mutation formation with long-wave ultraviolet light (UVA).},
  author={Thomas M. R{\"u}nger and Ulrike P Kappes},
  journal={Photodermatology, photoimmunology & photomedicine},
  year={2008},
  volume={24 1},
  pages={2-10}
}
Long-wave ultraviolet (UV) A light is able to damage DNA, to cause mutations, and to induce skin cancer, but the exact mechanisms of UVA-induced mutation formation remain a matter of debate. While pyrimidine dimers are well established to mediate mutation formation with shortwave UVB, other types of DNA damage, such as oxidative base damage, have long been thought to be the premutagenic lesions for UVA mutagenesis. However, pyrimidine dimers can also be generated by UVA, and there are several… CONTINUE READING