Mechanisms of monoclonal antibody stabilization and release from silk biomaterials.

@article{Guziewicz2013MechanismsOM,
  title={Mechanisms of monoclonal antibody stabilization and release from silk biomaterials.},
  author={Nicholas A Guziewicz and Andrew J Massetti and Bernardo J Perez-Ramirez and David L Kaplan},
  journal={Biomaterials},
  year={2013},
  volume={34 31},
  pages={7766-75}
}
The availability of stabilization and sustained delivery systems for antibody therapeutics remains a major clinical challenge, despite the growing development of antibodies for a wide range of therapeutic applications due to their specificity and efficacy. A mechanistic understanding of protein-matrix interactions is critical for the development of such systems and is currently lacking as a mode to guide the field. We report mechanistic insight to address this need by using well-defined… CONTINUE READING