Mechanisms of modified LDL-induced pericyte loss and retinal injury in diabetic retinopathy

@article{Fu2012MechanismsOM,
  title={Mechanisms of modified LDL-induced pericyte loss and retinal injury in diabetic retinopathy},
  author={Dongxu Fu and Mingyuan Wu and Jin Zhang and Mei Fang Du and Steve Ta-Shen Yang and Samar M Hammad and KennethS. Wilson and Jinfeng Chen and Timothy J Lyons},
  journal={Diabetologia},
  year={2012},
  volume={55},
  pages={3128-3140}
}
Aims/hypothesisIn previous studies we have shown that extravasated, modified LDL is associated with pericyte loss, an early feature of diabetic retinopathy (DR). Here we sought to determine detailed mechanisms of this LDL-induced pericyte loss.MethodsHuman retinal capillary pericytes (HRCP) were exposed to ‘highly-oxidised glycated’ LDL (HOG-LDL) (a model of extravasated and modified LDL) and to 4-hydroxynonenal or 7-ketocholesterol (components of oxidised LDL), or to native LDL for 1 to 24 h… CONTINUE READING
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