Mechanisms of mitotic inhibition in corneal endothelium: contact inhibition and TGF-beta2.

  title={Mechanisms of mitotic inhibition in corneal endothelium: contact inhibition and TGF-beta2.},
  author={Nancy C. Joyce and Deshea L. Harris and David M Mello},
  journal={Investigative ophthalmology & visual science},
  volume={43 7},
PURPOSE Contact inhibition has been implicated as an important antiproliferative mechanism in developing and mature corneal endothelium. Although exogenous TGF-beta2 and TGF-beta2 in aqueous humor suppress S-phase entry in cultured rat corneal endothelial cells, it is not known whether TGF-beta2 contributes to the mitotic inhibition that occurs during in vivo endothelial development. TGF-beta receptors I, II, and III must be coexpressed for a TGF-beta2-induced intracellular signal to be… CONTINUE READING


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