Mechanisms of methylmercury-induced neurotoxicity.

@article{Atchison1994MechanismsOM,
  title={Mechanisms of methylmercury-induced neurotoxicity.},
  author={William David Atchison and Michael F. Hare},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={1994},
  volume={8 9},
  pages={
          622-9
        }
}
Mercury in both organic and inorganic forms is neurotoxic. Methylmercury (MeHg) is a commonly encountered form of mercury in the environment. Early electrophysiological experiments revealed that MeHg potently affects the release of neurotransmitter from presynaptic nerve terminals. Recently, the hypothesis that these alterations may be mediated by changes in the intracellular concentration of Ca2+ ([Ca2+]i) has been supported. MeHg alters [Ca2+]i by at least two mechanisms. First, it disrupts… CONTINUE READING

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