Mechanisms of memory loss in A β and tau mouse models

@inproceedings{Ashe2005MechanismsOM,
  title={Mechanisms of memory loss in A β and tau mouse models},
  author={K. Ashe},
  year={2005}
}
Although memory loss is the central symptom of Alzheimer’s disease, the pathophysiological mechanisms leading to dementia are poorly understood. It is difficult to answer this issue with studies in humans and impossible in cultured cells. Therefore animal models are needed to elucidate the molecular mechanisms leading to dementia. The chief neuropathological changes during Alzheimer’s disease, namely neurofibrillary tangles and amyloid plaques, have helped us to determine which molecules to… CONTINUE READING

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