Mechanisms of malignant ascites production.

@article{Garrison1987MechanismsOM,
  title={Mechanisms of malignant ascites production.},
  author={Richard Neal Garrison and Rowena Galloway and Louis S. Heuser},
  journal={The Journal of surgical research},
  year={1987},
  volume={42 2},
  pages={
          126-32
        }
}
The accumulation of malignant ascites is determined primarily by the obstruction of diaphragmatic lymphatics with tumor inhibiting the outflow of peritoneal fluid. An abnormal increase in peritoneal fluid production has been shown to contribute to ascites formation by a marked neovascularization of the parietal peritoneum. Cell-free malignant ascitic fluid obtained from rats with intra-abdominal Walker 256 carcinoma when infused into the peritoneal cavities of normal animals causes an increase… CONTINUE READING
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