Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosis.

  title={Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosis.},
  author={Keisuke Kakisaka and Sophie C. Cazanave and Christian Dominik Fingas and Maria Eugenia Guicciardi and Steven F. Bronk and Nathan W. Werneburg and Justin L Mott and Gregory J. Gores},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  volume={302 1},
Isolated hepatocytes undergo lipoapoptosis, a feature of hepatic lipotoxicity, on treatment with saturated free fatty acids (FFA) such as palmitate (PA). However, it is unknown if palmitate is directly toxic to hepatocytes or if its toxicity is indirect via the generation of lipid metabolites such as lysophosphatidylcholine (LPC). PA-mediated hepatocyte lipoapoptosis is associated with endoplasmic reticulum (ER) stress, c-Jun NH(2)-terminal kinase (JNK) activation, and a JNK-dependent… CONTINUE READING