Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human

@article{Gillet2007MechanismsOL,
  title={Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human},
  author={Nicolas A. Gillet and Arnaud Florins and Mathieu Boxus and Catherine Burteau and Annamaria Nigro and Fabian Vandermeers and Herv{\'e} Balon and Amel Baya Bouzar and Julien Defoiche and Ars{\`e}ne Burny and Michal Reichert and Richard Kettmann and Lucas Willems},
  journal={Retrovirology},
  year={2007},
  volume={4},
  pages={18 - 18}
}
In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was considered to be the first reported case of bovine leukemia. The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the deltaretrovirus genus which also includes the related human T-lymphotropic virus type 1 (HTLV-1). This review summarizes current knowledge of this viral system, which is important as a model for leukemogenesis. Recently, the BLV model has also cast… CONTINUE READING
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