Mechanisms of leptin action and leptin resistance.

@article{Myers2008MechanismsOL,
  title={Mechanisms of leptin action and leptin resistance.},
  author={Martin G Myers and Michael Alexander Cowley and Heike M{\"u}nzberg},
  journal={Annual review of physiology},
  year={2008},
  volume={70},
  pages={537-56}
}
The adipose tissue-derived hormone leptin acts via its receptor (LRb) in the brain to regulate energy balance and neuroendocrine function. LRb signaling via STAT3 and a number of other pathways is required for the totality of leptin action. The failure of elevated leptin levels to suppress feeding and mediate weight loss in common forms of obesity defines a state of so-called leptin resistance. A number of mechanisms, including the leptin-stimulated phosphorylation of Tyr(985) on LRb and the… CONTINUE READING
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