Mechanisms of ischemic preconditioning and its application in transplantation.

Abstract

Ischemic preconditioning is a phenomenon of increased tissue resistance to ischemic injury evoked by brief intermittent periods of ischemia. Since its discovery in 1986, extensive studies were undertaken to explain its mechanisms and induce protection pharmacologically. There is convincing evidence on adenosine receptors, ATP-dependent potassium channels… (More)

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