Mechanisms of iron regulation in mycobacteria: role in physiology and virulence.

@article{Rodriguez2003MechanismsOI,
  title={Mechanisms of iron regulation in mycobacteria: role in physiology and virulence.},
  author={Galaxia M Rodriguez and Issar Smith},
  journal={Molecular microbiology},
  year={2003},
  volume={47 6},
  pages={1485-94}
}
The role of iron in mycobacteria as in other bacteria goes beyond the need for this essential cofactor. Limitation of this metal triggers an extensive response aimed at increasing iron acquisition while coping with iron deficiency. In contrast, iron-rich environments prompt these prokaryotes to induce synthesis of iron storage molecules and to increase mechanisms of protection against iron-mediated oxidative damage. The response to changes in iron availability is strictly regulated in order to… CONTINUE READING
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