Mechanisms of iron mediated regulation of the duodenal iron transporters divalent metal transporter 1 and ferroportin 1.

@article{Zoller2002MechanismsOI,
  title={Mechanisms of iron mediated regulation of the duodenal iron transporters divalent metal transporter 1 and ferroportin 1.},
  author={Heinz Zoller and Igor M Theurl and Robert W Koch and Arthur Kaser and Guenter Weiss},
  journal={Blood cells, molecules & diseases},
  year={2002},
  volume={29 3},
  pages={488-97}
}
Intestinal iron absorption is regulated by the body's demands for iron. Identification of divalent metal transporter 1 (DMT1) and ferroportin 1 (FPN1) has improved our understanding of iron transport across the intestinal epithelium. Although DMT1 and FPN1 mRNA bear an iron responsive element (IRE) within its untranslated regions which should cause susceptibility to iron mediated posttranscriptional regulation the latter has not been shown so far. The effects of iron perturbations on DMT1 and… CONTINUE READING

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