Mechanisms of iron loading and toxicity.

  title={Mechanisms of iron loading and toxicity.},
  author={Gregory J Anderson},
  journal={American journal of hematology},
  volume={82 12 Suppl},
Normal iron homeostasis is a finely balanced system that reflects iron absorption, loss and utilization. The body has no mechanism for the active excretion of iron, so body iron levels are controlled at the point of absorption in the small intestine. Disturbances in this equilibrium, such as those leading to enhanced absorption, can have significant clinical consequences. Continued excessive iron uptake is followed by iron deposition in various tissues, ultimately leading to tissue damage, and… CONTINUE READING

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