Mechanisms of ionic activation of adrenal mitochondrial cytochromes P-450scc and P-45011 beta.


The effects of metal ions on the enzymatic reduction of adrenodoxin, on cholesterol side chain cleavage, and on 11/3-hydroxylation, all catalyzed by purified enzymes, have been compared. Both monovalent and divalent ions activated adrenodoxin reduction by NADPH and adrenodoxin reductase, confirming previous findings (Lambeth, J . D., Seybert, D. W., and… (More)


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