Mechanisms of interleukin-1beta-induced GDNF release from rat glioma cells.

  title={Mechanisms of interleukin-1beta-induced GDNF release from rat glioma cells.},
  author={Kumiko Tanabe and Kazumi Nishimura and Shuji Dohi and Osamu Kozawa},
  journal={Brain research},
Glial cell line-derived neurotrophic factor (GDNF) is highly expressed both in neurons and astrocytes in injured tissues. Astrocytes support neurons by releasing neurotrophic factors including GDNF. It has been reported that various agents including cytokines such as interleukin (IL)-1beta induce GDNF mRNA expression and the release in astrocytes. However, the mechanism behind the GDNF synthesis and release remains unclear. Herein, we investigated the mechanisms of the IL-1beta-induced GDNF… CONTINUE READING


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