Mechanisms of injury in the central nervous system.

  title={Mechanisms of injury in the central nervous system.},
  author={Martin A. Philbert and Melvin L. Billingsley and Kenneth R. Reuhl},
  journal={Toxicologic pathology},
  volume={28 1},
Neurotoxicants with similar structural features or common mechanisms of chemical action frequently produce widely divergent neuropathologic outcomes. Methylmercury (MeHg) produces marked cerebellar dysmorphogenesis during critical periods of development. The pathologic picture is characterized by complete architectural disruption of neuronal elements within the cerebellum. MeHg binds strongly to protein and soluble sulphydryl groups. Binding to microtubular -SH groups results in catastrophic… CONTINUE READING