Mechanisms of inhibitory action of TRK-130 (Naltalimide), a μ-opioid receptor partial agonist, on the micturition reflex

@article{Fujimura2017MechanismsOI,
  title={Mechanisms of inhibitory action of TRK-130 (Naltalimide), a μ-opioid receptor partial agonist, on the micturition reflex},
  author={Morihiro Fujimura and N. Izumimoto and S. Kanie and R. Kobayashi and Satoru Yoshikawa and Shinobu Momen and Mikito Hirakata and Toshikazu Komagata and S. Okanishi and M. Iwata and Tadatoshi Hashimoto and T. Doi and N. Yoshimura and K. Kawai},
  journal={International Urology and Nephrology},
  year={2017},
  volume={49},
  pages={587-595}
}
  • Morihiro Fujimura, N. Izumimoto, +11 authors K. Kawai
  • Published 2017
  • Medicine
  • International Urology and Nephrology
  • PurposeTo clarify the mechanism of inhibitory action of TRK-130 (Naltalimide), a unique µ-opioid receptor partial agonist, on the micturition reflex.MethodsThe effect of TRK-130 on isovolumetric rhythmic bladder contractions (RBCs) was examined in guinea pigs, the effect of which was clarified by co-treatment with naloxone or in spinal cord transection. The effect of TRK-130 on urodynamic parameters was also observed in guinea pigs. In addition, the effect of TRK-130 on bladder contraction… CONTINUE READING
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