Mechanisms of inhibition of lipolysis by insulin, vanadate and peroxovanadate in rat adipocytes.

Abstract

Vanadate and peroxovanadate (pV), potent inhibitors of tyrosine phosphatases, mimic several of the metabolic actions of insulin. Here we compare the mechanisms for the anti-lipolytic action of insulin, vanadate and pV in rat adipocytes. Vanadate (5 mM) and pV (0.01 mM) inhibited lipolysis induced by 0.01-1 microM isoprenaline, vanadate being more and pV… (More)

Topics

9 Figures and Tables

Cite this paper

@article{Castan1999MechanismsOI, title={Mechanisms of inhibition of lipolysis by insulin, vanadate and peroxovanadate in rat adipocytes.}, author={Isabelle Castan and Jonny Wijkander and Vincenzo Manganiello and Eva Degerman}, journal={The Biochemical journal}, year={1999}, volume={339 ( Pt 2)}, pages={281-9} }