Mechanisms of inhibition and potentiation of α4β2 nicotinic acetylcholine receptors by members of the Ly6 protein family.

@article{Wu2015MechanismsOI,
  title={Mechanisms of inhibition and potentiation of α4β2 nicotinic acetylcholine receptors by members of the Ly6 protein family.},
  author={Meilin Wu and Clare A. Puddifoot and Palmer Taylor and William J. Joiner},
  journal={The Journal of biological chemistry},
  year={2015},
  volume={290 40},
  pages={24509-18}
}
α4β2 nicotinic acetylcholine receptors (nAChRs) are abundantly expressed throughout the central nervous system and are thought to be the primary target of nicotine, the main addictive substance in cigarette smoking. Understanding the mechanisms by which these receptors are regulated may assist in developing compounds to selectively interfere with nicotine addiction. Here we report previously unrecognized modulatory properties of members of the Ly6 protein family on α4β2 nAChRs. Using a FRET… CONTINUE READING