Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase.

@article{Guzik2002MechanismsOI,
  title={Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase.},
  author={Tomasz J Guzik and Shafi Mussa and Daniela Gastaldi and J. N. von Sadowski and Champa N. Ratnatunga and Ravi Kumar Pillai and Keith M. Channon},
  journal={Circulation},
  year={2002},
  volume={105 14},
  pages={
          1656-62
        }
}
BACKGROUND Increased superoxide production contributes to reduced vascular nitric oxide (NO) bioactivity and endothelial dysfunction in experimental models of diabetes. We characterized the sources and mechanisms underlying vascular superoxide production in human blood vessels from diabetic patients with coronary artery disease compared with nondiabetic patients. METHODS AND RESULTS Vascular superoxide production was quantified in both saphenous veins and internal mammary arteries from 45… CONTINUE READING

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