Mechanisms of impaired endothelium-dependent cerebral vasodilatation in response to bradykinin in hypertensive rats.

@article{Yang1991MechanismsOI,
  title={Mechanisms of impaired endothelium-dependent cerebral vasodilatation in response to bradykinin in hypertensive rats.},
  author={Stru turesChia-Lin Yang and William G Mayhan and Frank M. Faraci and Donald D. Heistad},
  journal={Stroke},
  year={1991},
  volume={22 9},
  pages={1177-82}
}
Bradykinin produces less dilatation of pial arterioles in stroke-prone spontaneously hypertensive rats than in normotensive Wistar-Kyoto rats. The goals of this study were to determine the mediator of bradykinin-induced dilatation in cerebral arterioles of rats and to determine whether responses to this mediator are altered in hypertensive rats. Diameter of… CONTINUE READING