Mechanisms of impaired biliary excretion of acetaminophen glucuronide after acute phenobarbital treatment or phenobarbital pretreatment.

@article{Xiong2002MechanismsOI,
  title={Mechanisms of impaired biliary excretion of acetaminophen glucuronide after acute phenobarbital treatment or phenobarbital pretreatment.},
  author={Hao Xiong and Hiroshi Suzuki and Yuichi Sugiyama and Peter J. Meier and Gary M. Pollack and Kim L. R. Brouwer},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2002},
  volume={30 9},
  pages={
          962-9
        }
}
Previous studies have demonstrated that phenobarbital (PB) significantly impairs the biliary excretion of acetaminophen glucuronide (AG) in rats. Studies also suggested that Mrp2 mediates AG biliary excretion, and Mrp3 is involved in AG basolateral export. It was hypothesized that inhibition of Mrp2-mediated AG transport by PB or PB metabolites, and PB induction of Mrp3, may contribute to the impaired biliary excretion of AG by PB. In the present study, the hepatobiliary transport of AG in… CONTINUE READING

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