Mechanisms of impaired anticryptococcal activity of monocytes from donors infected with human immunodeficiency virus.

@article{Harrison1997MechanismsOI,
  title={Mechanisms of impaired anticryptococcal activity of monocytes from donors infected with human immunodeficiency virus.},
  author={Thomas Stephen Harrison and Stuart M Levitz},
  journal={The Journal of infectious diseases},
  year={1997},
  volume={176 2},
  pages={537-40}
}
The mechanisms by which monocytes from patients infected with human immunodeficiency virus (HIV) have reduced growth inhibitory activity against Cryptococcus neoformans was examined. Monocyte-enriched peripheral blood mononuclear cells from 12 HIV-seropositive donors with CD4 cell counts of 10-210 cells/mm3 (median, 85) and HIV-seronegative donors were compared in assays to determine the binding and phagocytosis of C. neoformans and the respiratory burst and degranulation in response to C… CONTINUE READING

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