Mechanisms of impaired acute insulin release in adult onset diabetes: studies with isoproterenol and secretin.

@article{Halter1978MechanismsOI,
  title={Mechanisms of impaired acute insulin release in adult onset diabetes: studies with isoproterenol and secretin.},
  author={J. Halter and D. Porte},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1978},
  volume={46 6},
  pages={
          952-60
        }
}
  • J. Halter, D. Porte
  • Published 1978
  • Medicine
  • The Journal of clinical endocrinology and metabolism
Previous work has suggested that impaired islet glucose recognition occurs in patients with adult onset diabetes, as acute insulin release is absent after iv glucose but present after beta adrenergic stimulation with isoproterenol (Iso). However, insulin responses to Iso were variably reduced as compared to normal in the diabetics. In order to evaluate the importance of the Iso dose, dose-response studies were performed in 9 diabetics (fasting plasma glucose greater than 150 mg/dl) and 10 age… Expand
Paradoxical inhibition of insulin secretion by glucose in human diabetes mellitus.
Pathophysiology of insulin secretion in diabetes mellitus.
Augmented insulin responses to glucose after secretin priming in diabetic subjects.
  • R. Lerner
  • Medicine
  • The Journal of clinical endocrinology and metabolism
  • 1979
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SECRETIN-INDUCED INSULIN RESPONSE
Studies of secretin-stimulated insulin responses in man.
Epinephrine: selective inhibition of the acute insulin response to glucose.
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