Mechanisms of immunotherapy: IgG revisited.

  title={Mechanisms of immunotherapy: IgG revisited.},
  author={Petra A. Wachholz and Stephen R. Durham},
  journal={Current opinion in allergy and clinical immunology},
  volume={4 4},
PURPOSE OF REVIEW This paper will review historical and recent evidence for the induction of 'blocking' IgG antibodies during successful specific immunotherapy. RECENT FINDINGS Specific immunotherapy is frequently associated with a rise in allergen-specific IgG4 antibodies and a modest reduction in specific IgE titres, although this does not always correlate with clinical efficacy. There is accumulating evidence that specific immunotherapy also influences the blocking activity on IgE-mediated… CONTINUE READING

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