Mechanisms of immunomodulation by mammalian and viral decoy receptors: insights from structures

@article{Felix2017MechanismsOI,
  title={Mechanisms of immunomodulation by mammalian and viral decoy receptors: insights from structures},
  author={Jan Felix and Savvas N. Savvides},
  journal={Nature Reviews Immunology},
  year={2017},
  volume={17},
  pages={112-129}
}
Immune responses are regulated by effector cytokines and chemokines that signal through cell surface receptors. Mammalian decoy receptors — which are typically soluble or inactive versions of cell surface receptors or soluble protein modules termed binding proteins — modulate and antagonize signalling by canonical effector–receptor complexes. Viruses have developed a diverse array of molecular decoys to evade host immune responses; these include viral homologues of host cytokines, chemokines… Expand
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