Mechanisms of immune tolerance to allergens: role of IL-10 and Tregs.

  title={Mechanisms of immune tolerance to allergens: role of IL-10 and Tregs.},
  author={Cezmi A. Akdis and M{\"u}beccel Akdis},
  journal={The Journal of clinical investigation},
  volume={124 11},
During the past 20 years, major advances have been made in understanding the molecular and cellular mechanisms of allergen tolerance in humans. The demonstration of T cell tolerance, particularly that mediated by the immune-suppressive functions of IL-10, led to a major conceptual change in this area. Currently, the known essential components of allergen tolerance include the induction of allergen-specific regulatory subsets of T and B cells, the immune-suppressive function of secreted factors… CONTINUE READING
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