Mechanisms of immune escape in central nervous system infection with neurotropic JC virus variant.

@article{Jelcic2016MechanismsOI,
  title={Mechanisms of immune escape in central nervous system infection with neurotropic JC virus variant.},
  author={Ivan Jelcic and Ilijas Jel{\vc}i{\'c} and Christian Kempf and Fabienne Largey and Raquel Planas and Sven Schippling and H Budka and Mireia Sospedra and Roland Martin},
  journal={Annals of neurology},
  year={2016},
  volume={79 3},
  pages={404-18}
}
OBJECTIVE Symptomatic infections of the central nervous system (CNS) with JC polyomavirus (JCV) usually occur as a result of immunocompromise and manifest as progressive multifocal leukoencephalopathy (PML) or granule cell neuronopathy (GCN). After immune reconstitution, some of these cases may show long-term persistence of JCV and delayed clinical improvement despite inflammation. METHODS We followed 4 patients with multiple sclerosis, who developed natalizumab-associated PML or GCN with… CONTINUE READING
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