Mechanisms of hypoxic neurodegeneration in the developing brain.

  title={Mechanisms of hypoxic neurodegeneration in the developing brain.},
  author={Michael V Johnston and Wako Nakajima and Henrik H Hagberg},
  journal={The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry},
  volume={8 3},
Asphyxia and other insults to the developing brain are responsible for several human neurodevelopmental disorders. The pattern of neonatal brain injury differs from that seen in the adult nervous system, and there are wide differences in regional vulnerability. Recent evidence suggests that two events that contribute to this pattern of selective vulnerability are developmental changes in excitatory glutamate-containing neurotransmitter circuits and the propensity for immature neurons to die by… CONTINUE READING
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