Mechanisms of hypoxic gene regulation of angiogenesis factor Cyr61 in melanoma cells.

@article{Kunz2003MechanismsOH,
  title={Mechanisms of hypoxic gene regulation of angiogenesis factor Cyr61 in melanoma cells.},
  author={Manfred Kunz and Steffen M{\"o}ller and Dirk Koczan and Peter Lorenz and Roland H. Wenger and Michael O. Glocker and Hans-J{\"u}rgen Thiesen and Gerd Gross and Saleh Mohamed Ibrahim},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 46},
  pages={45651-60}
}
Hypoxia has a profound influence on progression and metastasis of malignant tumors. In the present report, we used the oligonucleotide microarray technique to identify new hypoxia-inducible genes in malignant melanoma with a special emphasis on angiogenesis factors. A commercially available Affymetrix gene chip system was used to analyze five melanoma cell lines of different aggressiveness. A total of 160 hypoxia-inducible genes were identified, clustering in four different functional clusters… CONTINUE READING