Mechanisms of hypouricemia in the syndrome of inappropriate secretion of antidiuretic hormone.

@article{Decaux1985MechanismsOH,
  title={Mechanisms of hypouricemia in the syndrome of inappropriate secretion of antidiuretic hormone.},
  author={Guy Decaux and Isabelle Dumont and Y Waterlot and Bill Hanson},
  journal={Nephron},
  year={1985},
  volume={39 3},
  pages={164-8}
}
Hypouricemia seen with hyponatremia related to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) results from an increase in uric acid renal clearance. We studied the mechanism of the increase of uric acid excretion in 6 SIADH patients through pyrazinamide (PZA), which decreases tubular secretion of uric acid, and sulfinpyrazone (SPZ) which decreases post-secretory reabsorption of uric acid. 3 g of PZA decreased the absolute uric acid excretion from 428 +/- 244 to 105… CONTINUE READING

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