Mechanisms of hypotonicity-induced calcium signaling and integrin activation by arachidonic acid-derived inflammatory mediators in B cells.

@article{Zhu2005MechanismsOH,
  title={Mechanisms of hypotonicity-induced calcium signaling and integrin activation by arachidonic acid-derived inflammatory mediators in B cells.},
  author={Peimin Zhu and Xiaohong Liu and Edward F. Labelle and Bruce D Freedman},
  journal={Journal of immunology},
  year={2005},
  volume={175 8},
  pages={4981-9}
}
We previously characterized the initial steps in the activation of novel (calcium-permeant) nonselective cation channels (NSCCs) and calcium release-activated calcium channels in primary murine B lymphocytes. Phospholipase C products, namely diacylglycerol and d-myo-inositol 1,4,5-trisphosphate, were identified as proximal intracellular agonists of these respective channels following mechanical stimulation of B cells. However, neither the distal steps in NSCC activation nor the contribution of… CONTINUE READING
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