Mechanisms of hyperuricemia in cyclosporine-treated renal transplanted children.

  title={Mechanisms of hyperuricemia in cyclosporine-treated renal transplanted children.},
  author={Juhani Laine and Christer Holmberg},
  volume={74 2},
Mechanisms of hyperuricemia were investigated in 19 pediatric renal transplant recipients 6 months after transplantation. 51Cr-EDTA, PAH, lithium and sodium clearances, 24-hour urinary creatinine and urate excretions were measured. Ten patients had hyperuricemia. The hyperuricemic patients had lower EDTA, PAH, and urate clearances (mean 69.5 vs. 92.5, p < 0.05, 234 vs. 421, p < 0.05 and 4.3 vs. 10.6 ml/min/1.73 m2, p < 0.001, respectively). Serum urate concentration correlated with cyclosporine… CONTINUE READING
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