Mechanisms of hypergammaglobulinemia in pulmonary sarcoidosis. Site of increased antibody production and role of T lymphocytes.

@article{Hunninghake1981MechanismsOH,
  title={Mechanisms of hypergammaglobulinemia in pulmonary sarcoidosis. Site of increased antibody production and role of T lymphocytes.},
  author={Gary W. Hunninghake and Ronald G. Crystal},
  journal={The Journal of clinical investigation},
  year={1981},
  volume={67 1},
  pages={86-92}
}
Pulmonary sarcoidosis is a disorder in which local granuloma formation is perpetuated by activated lung T lymphocytes. The present study suggests that lung T lymphocytes may also play a critical role in modulating local production of antibodies in this disorder. In untreated patients with pulmonary sarcoidosis, the numbers of IgG- and IgM-secreting cells per 10(3) lung lymphocytes are markedly increased compared with those in normal individuals (P < 0.001 and P < 0.01, respectively); the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 43 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 22 references

Pulmonary sarcoidosis: a disease characterized and perpetuated by activated lung T-lymphocytes

  • R G Crystal, W C Roberts, G W Hunninghake, J E Gadek, J D Fulmer, B R Line
  • Ann. Intern. Med
  • 1980

Similar Papers

Loading similar papers…