Mechanisms of human neutrophil oxidant production after severe injury.

@article{Quaid2001MechanismsOH,
  title={Mechanisms of human neutrophil oxidant production after severe injury.},
  author={Gina Quaid and Cindy M. Cave and Mark A. Williams and Robert F. Hennigan and Gary M. Bokoch and Joseph S. Solomkin},
  journal={Surgery},
  year={2001},
  volume={130 4},
  pages={669-75; discussion 675-6}
}
BACKGROUND The purpose of this study was to determine the mechanisms of enhanced oxidant production after severe injury. METHODS Neutrophils were harvested from patients within 24 hours of admission who had an injury severity score greater than 16. Nonadherent and adherent neutrophil oxidant production was measured after N-formyl-methionyl-leucyl-phenylalanine (fMLP) stimulation. Translocation of cytochrome b558 and cytosolic components p47phox and p67phox were determined by oxidation… CONTINUE READING