Mechanisms of human autoimmunity.

  title={Mechanisms of human autoimmunity.},
  author={Michael D Rosenblum and Kelly A Remedios and Abul K Abbas},
  journal={The Journal of clinical investigation},
  volume={125 6},
Autoimmune reactions reflect an imbalance between effector and regulatory immune responses, typically develop through stages of initiation and propagation, and often show phases of resolution (indicated by clinical remissions) and exacerbations (indicated by symptomatic flares). The fundamental underlying mechanism of autoimmunity is defective elimination and/or control of self-reactive lymphocytes. Studies in humans and experimental animal models are revealing the genetic and environmental… CONTINUE READING
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