Mechanisms of human DNA repair: an update.

@article{Christmann2003MechanismsOH,
  title={Mechanisms of human DNA repair: an update.},
  author={Markus Christmann and Maja T Tomicic and Wynand Paul Roos and Bernd Kaina},
  journal={Toxicology},
  year={2003},
  volume={193 1-2},
  pages={3-34}
}
The human genome, comprising three billion base pairs coding for 30000-40000 genes, is constantly attacked by endogenous reactive metabolites, therapeutic drugs and a plethora of environmental mutagens that impact its integrity. Thus it is obvious that the stability of the genome must be under continuous surveillance. This is accomplished by DNA repair mechanisms, which have evolved to remove or to tolerate pre-cytotoxic, pre-mutagenic and pre-clastogenic DNA lesions in an error-free, or in… CONTINUE READING
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