Mechanisms of host wasting induced by administration of cytokines in rats.

@article{Ling1997MechanismsOH,
  title={Mechanisms of host wasting induced by administration of cytokines in rats.},
  author={P R Ling and John H. Schwartz and Bruce R Bistrian},
  journal={The American journal of physiology},
  year={1997},
  volume={272 3 Pt 1},
  pages={
          E333-9
        }
}
This study determined the effects of chronic administration of the two principal proximate cytokines, interleukin-1 (IL-1) and tumor necrosis factor (TNF), on host wasting in rats. The effects were compared with those observed in a matched pair-fed group to distinguish the contribution from anorexia. Both TNF and IL-1 produced weight loss, net nitrogen loss, and skeletal muscle catabolism and increased liver weight. Such effects were independent from and additive to those resulting from… CONTINUE READING

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