Mechanisms of host cell invasion by Trypanosoma cruzi.

  title={Mechanisms of host cell invasion by Trypanosoma cruzi.},
  author={Kacey L Caradonna and Barbara A Burleigh},
  journal={Advances in parasitology},
One of the more accepted concepts in our understanding of the biology of early Trypanosoma cruzi-host cell interactions is that the mammalian-infective trypomastigote forms of the parasite must transit the host cell lysosomal compartment in order to establish a productive intracellular infection. The acidic environment of the lysosome provides the appropriate conditions for parasite-mediated disruption of the parasitophorous vacuole and release of T. cruzi into the host cell cytosol, where… CONTINUE READING
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