Mechanisms of hormonal regulation of hepatic glucose metabolism.

  title={Mechanisms of hormonal regulation of hepatic glucose metabolism.},
  author={John H. Exton},
  journal={Diabetes/metabolism reviews},
  volume={3 1},
Acute hormonal regulation of liver carbohydrate metabolism mainly involves changes in the cytosolic levels of cAMP and Ca2+. Epinephrine, acting through beta 2-adrenergic receptors, and glucagon activate adenylate cyclase in the liver plasma membrane through a mechanism involving a guanine nucleotide-binding protein that is stimulatory to the enzyme. The resulting accumulation of cAMP leads to activation of cAMP-dependent protein kinase, which, in turn, phosphorylates many intracellular enzymes… CONTINUE READING


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